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  • The Greeks really do have near-mythical origins, ancient DNA reveals

    The Greeks really do have near-mythical origins, ancient DNA reveals

    2017-09-07

    Ever since the days of Homer, Greeks have long idealized their Mycenaean “ancestors” in epic poems and classic tragedies that glorify the exploits of Odysseus, King Agamemnon, and other heroes who went in and out of favor with the Greek gods. Although these Mycenaeans were fictitious, scholars have debated whether today’s Greeks descend from the actual Mycenaeans, who created a famous civilization......

  • Anticancer immunotherapy by CTLA-4 blockade relies on the gutmicrobiota

    Anticancer immunotherapy by CTLA-4 blockade relies on the gutmicrobiota

    2017-09-07

    Antibodies targeting CTLA-4 have been successfully used as cancer immunotherapy. We find that theantitumor effects of CTLA-4 blockade depend on distinct Bacteroides species. In mice and patients, T cell responses specific for B. thetaiotaomicron or B. fragilis were associated with the efficacy of CTLA-4blockade. Tumors in antibiotic-treated or germ-free mice did not respond to CTLA blockade. This ......

  • How elephants crush cancer

    How elephants crush cancer

    2017-09-07

    Why elephants aren’t riddled with tumors poses a weighty problem for researchers. A new study shows that the animals harbor dozens of extra copies of one of the most powerful cancer-preventing genes. These bonus genes might enable elephants to weed out potentially cancerous cells before they can grow into tumors.

  • Multiple repressive mechanisms in the hippocampus during memory formation

    Multiple repressive mechanisms in the hippocampus during memory formation

    2017-09-07

    Memory stabilization after learning requires translational and transcriptional regulations in the brain, yet the temporal molecular changes that occur after learning have not been explored at the genomic scale.