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Colchicine

Colchicine

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Product Description

Colchicine



Colchicine 


Colchicine is a medication most commonly used to treat gout. It is a toxic natural product and secondary metabolite, originally extracted from plants of the genus Colchicum (autumn crocus, Colchicum autumnale, also known as "meadow saffron"). 

The plant source of colchicine, the autumn crocus (Colchicum autumnale), was described for treatment of rheumatism and swelling in the Ebers Papyrus (circa 1500 BC), an Egyptian medical papyrus. Colchicum extract was first described as a treatment for gout in De Materia Medica by Pedanius Dioscorides, in the first century AD. 

Colchicine was first isolated in 1820 by the French chemists P. S. Pelletier and J. B.CaventouIn 1833, P.L. Geiger purified an active ingredient, which he named colchicine.

Adverse effects are primarily gastrointestinal upset at high doses. In addition to gout, colchicine is used to treat familial Mediterranean feverpericarditis and Behçet's disease.



Colchicine

Chemical Name

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzo[a]heptalen-7-yl]acetamide

Plant Part Used

Gloriosa Superba Seeds

CAS Number

64-86-8

EINECS Number

200-598-5

Molecular Formula

C22H25NO6

Molecular Weight

399.437

Melting Point

150-160℃

Boiling Point

726℃ at 760 mmHg

Density

1.25g/cm3

Flash Point

392.9℃

Vapour Pressure

6.21E-21mmHg at 25℃

Appearance

White to yellowish white amorphous/crystalline powder

Hazard codes

T+: Very toxic

Specification

USP,98%min HPLC

Water solubility

45 g/L (20℃)

Solubility

Very soluble in cold water, ethanol and chloroform. Slightly soluble in ether. Not soluble in hot water.

Package

HDPE drum outside and aluminum foil bag inside. Or as required

Storage

Store in cold, dry, ventilated and sealing area.

Shelf life

Two years




Certificate of Analysis

Product Name: Colchicine USP

Batch No.: BOZ/COL/17/FEB/25

Plant Part Used: Gloriosa Superba Seeds

Quantity: 20.0kgs

Manufacturing Date: Feb. 2017

Pack Size: 1.0kgs*20Packs

Retest Date: Feb.2022

Country of Origin: China

 

TEST

SPECIFICATION

RESULT

Appearance

White to yellowish white amorphous/crystalline powder.

Pale yellow crystalline powder

Solubility

Soluble in water, freely soluble in alcohol and in chloroform, slightly soluble in ether.

Complies

Identification by IR

To comply IR

Complies

Specific Optical Rotation

-240°to -250°

-243°

Water Content

NMT 2.0% w/w

1.2% % w/w

Particle Size

95% passes through 80 mesh

98% passes through 80 mesh

Assay (by HPLC)

94.0% to 101.0%

98.1%

Colchiceine

NMT 0.2%

0.2%

Residual Solvents:

Ethyl acetate

Dichloromethane

IPA

Ethyle alcohol

Methanol

Chloroform

 

NMT 6.0%

NMT 600 ppm

NMT 5000 ppm

NMT 5000 ppm

NMT 3000 ppm

NMT 60 ppm

 

3.5%

Not detected

155ppm

Not detected

185ppm

Not detected

Chromatographic purity

NMT 5.0%

1.8%

Conclusion: The above analysis results comply with the specification. Customer is advised to verify the results before use.

Note: Since it is a natural extract, there is likely to be minor color variation from batch to batch because of the seasonal

 variations of the raw material. Color change will not affect the quality and efficacy of the product.